Abstract 46: Whole Eye Transplantation in the Rodent: Long-Term Survival and Effects on the Unoperated Partner Eye
نویسندگان
چکیده
PURPOSE: The achievement of tolerance induction in Vascularized composite allografts (VCA) could potentially enhance the quality of life for patients with severe facial or extremity injuries while avoiding the risk of immunosuppression. The achievement of tolerance would help transitioning VCA from an experimental to a routine practice worldwide. The purpose of this study was to investigate strategies for tolerance induction in a large animal model and to assess whether current VCA recipients could potentially be weaned off of immunosuppression while maintaining their intact graft using only a co-stimulation blockade agent.
منابع مشابه
Abstract 47: Delayed Tolerance Induction Protocol for Vascularized Composite Allografts in Non-Human Primates: The Immunomodulatory Effect of Donor Bone Marrow Transplantation Does Not Prevent the Development of Chronic Rejection in the Absence of Durable Mixed Chimerism
PURPOSE: Globally, 39 million people suffer from blindness. Whole eye transplantation (WET) offers the opportunity to provide a viable optical system to recipients with irreversible vision loss. We have previously established a viable orthotropic model for vascularized whole eye transplant in the rat. The purpose of our study is to evaluate gross morphology, structural integrity and aqueous hum...
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Background & Aim: Delayed graft function(DGF) generally refers to oliguria or the requirement for dialysis in the first week post-transplantation. It is the earliest and most frequent post- transplantation complication that can occur. DGF is an extremely important post- transplantation complication because its occurrence has short-term or long-term consequences for allograft survival. Howev...
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